Sirena Panama Canal cruise from Miami

From Miami, Florida, cruises to the Panama Canal visit both Central American and Caribbean locations. Crossing the Panama Canal by ship is a once-in-a-lifetime experience. While going to or coming from the Panama Canal, one of the greatest man-made wonders in the world, go deep into the Panamanian rain forest, meet the locals, and learn how the locks work.

Panama Canal Ports of Call

Panama Canal cruise from Miami include stops in some of the most breathtaking beaches and crystal-clear waters in the world.

• Panama: A Miami departure to Panama offers the unique experience of cruising through the iconic Panama Canal and exploring its surrounding tropical biodiversity.

Duration

There are various Panama Canal itineraries departing from Miami in 2025, ranging from to days.

Cruise Types

Nearly all cruises departing from Miami are roundtrip cruise.