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12-day cruise from Miami

12-day cruise from Miami A 12-day cruise from Miami, Florida, is the perfect option to make a short getaway feel like a much longer period of repose, offering you the chance to unwind without the hassle. The beauty of a 12-day Eastern, Western, or Southern Caribbean cruise is that you only have to unpack once and settle into one room, yet still experience a rich variety of cultures, landscapes, and destinations. On a 12-day cruise, you'll see a wide variety of Western, Southern, or Eastern Caribbean ports and have ample time at sea to enjoy all of the incredible amenities and services on board, from world-class dining to luxurious staterooms and innovative lounges. Whether you enjoy adventure activities like snorkeling and scuba diving or prefer more laid-back activities like beach reading and sipping a chilled beverage, there is a tropical island right for you.

12-day destinations out of Miami

Discover the diverse range of exciting destinations you can visit on 12-day cruises departing from PortMiami, offering unique experiences and adventures in the Caribbean and beyond.

  • Enjoy Bermuda's unique blend of British charm and island soul, renowned for its pink-sand beaches and vibrant coral reefs. Explore cruises to Bermuda.
  • Experience the vibrant cultures and breathtaking landscapes of the Eastern Caribbean, from lush rainforests to idyllic beaches. Explore cruises to Eastern Caribbean.
  • Witness the engineering marvel of the Panama Canal and explore the rich history and diverse ecosystems surrounding this iconic waterway. Explore cruises to Panama Canal.
  • Venture to the Southern Caribbean to uncover hidden gems with less-traveled roads and intimate, peaceful islands. Explore cruises to Southern Caribbean.
  • Embrace the dynamic spirit of the Western Caribbean, featuring ancient ruins, diverse ecosystems, and lively cultures. Explore cruises to Western Caribbean.

Cruise lines departing from Miami

The world's most renowned cruise lines welcome cruisers at PortMiami, offering a variety of memorable 12-day cruise experiences.

  • Azamara Club Cruises: Embark on a luxurious journey in the Caribbean, where immersive experiences await you.
  • Oceania Cruises: Indulge in exquisite cuisine and refined exploration in the breathtaking Caribbean.
  • Regent Seven Seas Cruises: Discover the epitome of all-inclusive luxury at sea.
  • Seabourn: Experience intimate luxury with extraordinary moments at sea as you sail through the Caribbean.

12-day Cruise Itineraries and Schedule from Miami

A wonderful tropical vacation can be had by setting sail from Miami on a 12-day cruise. Take a 12-day tropical cruise out of Miami and explore the islands in the Bermuda, Eastern Caribbean, Panama Canal, Southern Caribbean, Western Caribbean, all while soaking up the laid-back island vibe.

Price from: $ 2,159
latest updates:
For the latest updates about this itinerary, check at Azamara Club Cruises website
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12-day
Eastern Caribbean
cruise from Miami
onboard Azamara Onward

Departure Date: Sunday, November 30, 2025

Azamara Club Cruises Eastern Caribbean 12-day route to San Juan, St. John, St. Maarten, Antigua, St. Kitts, Charlestown, Virgin Gorda

Line Name: Azamara Club Cruises

Ship Name: Azamara Onward

Duration: 12-day cruise

Cruise Type: Roundtrip cruise

Ports of Call: Miami (6:00pm), San Juan (9:00am-10:00pm), St. John (8:00am-6:00pm), St. Maarten (8:00am-10:00pm), Antigua (8:00am-6:00pm), St. Kitts (8:00am-6:00pm), Charlestown (8:00am-6:00pm), Virgin Gorda (8:00am-62:00pm), Miami (6:00am);

Price from: $ 6,670
latest updates:
For the latest updates about this itinerary, check at Regent Seven Seas Cruises website
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12-day
Eastern Caribbean
cruise from Miami
onboard Seven Seas Grandeur

Departure Date: Monday, December 22, 2025

Regent Seven Seas Cruises Eastern Caribbean 12-day route to St. Kitts, Antigua, Fort-De-France, Bridgetown, St. Georges, Castries, St. Maarten

Line Name: Regent Seven Seas Cruises

Ship Name: Seven Seas Grandeur

Duration: 12-day cruise

Cruise Type: Holiday cruise

Ports of Call: Miami (5:00pm), St. Kitts (11:00am-8:00pm), Antigua (8:00am-6:00pm), Fort-De-France (8:00am-6:00pm), Bridgetown (8:00am-7:00pm), St. Georges (8:00am-8:00pm), Castries (7:00am-3:00pm), St. Maarten (9:00am-4:00pm), Miami (7:00am);

Price from: $ 7,978
latest updates:
For the latest updates about this itinerary, check at Regent Seven Seas Cruises website
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12-day
Panama Canal
cruise from Miami
onboard Seven Seas Grandeur

Departure Date: Saturday, January 3, 2026

Regent Seven Seas Cruises Panama Canal 12-day route to George Town, Ocho Rios, Bonaire, Curacao, Aruba, Cartagena, Puerto Limon, Panama Canal

Line Name: Regent Seven Seas Cruises

Ship Name: Seven Seas Grandeur

Duration: 12-day cruise

Cruise Type: One-way cruise

Ports of Call: Miami (5:00pm), George Town (9:00am-5:00pm), Ocho Rios (10:00am-6:00pm), Bonaire (10:00am-8:00pm), Curacao (7:00am-7:00pm), Aruba (7:00am-3:00pm), Cartagena (1:00pm-11:00pm), Puerto Limon (7:00am-4:00pm), Panama Canal (At Sea), Panama City (7:00am);

Price from: $ 5,057
latest updates:
For the latest updates about this itinerary, check at Oceania Cruises website
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12-day
Western Caribbean
cruise from Miami
onboard Allura

Departure Date: Sunday, January 4, 2026

Oceania Cruises Western Caribbean 12-day route to Cozumel, Costa Maya, Belize City, Santo Tomas, Roatan, Montego Bay, George Town, Key West

Line Name: Oceania Cruises

Ship Name: Allura

Duration: 12-day cruise

Cruise Type: Roundtrip cruise

Ports of Call: Miami (7:00pm), Cozumel (7:00am-5:00pm), Costa Maya (7:00am-5:00pm), Belize City (8:00am-5:00pm), Santo Tomas (7:00am-5:00pm), Roatan (7:00am-5:00pm), Montego Bay (7:00am-4:00pm), George Town (7:00am-6:00pm), Key West (7:00am-6:00pm), Miami (8:00am);

Price from: $ 3,858
latest updates:
For the latest updates about this itinerary, check at Oceania Cruises website
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12-day
Southern Caribbean
cruise from Miami
onboard Insignia

Departure Date: Thursday, January 15, 2026

Oceania Cruises Southern Caribbean 12-day route to Aruba, Curacao, Port of Spain, St. Georges, Castries, Kingstown, Roseau, Fort-de-France

Line Name: Oceania Cruises

Ship Name: Insignia

Duration: 12-day cruise

Cruise Type: Roundtrip cruise

Ports of Call: Miami (5:00pm), Aruba (11:00am-10:00pm), Curacao (7:00am-5:00pm), Port of Spain (7:00am-5:00pm), St. Georges (7:00am-5:00pm), Castries (7:00am-5:00pm), Kingstown (7:00am-5:00pm), Roseau (7:00am-5:00pm), Fort-de-France (7:00am-5:00pm), Bridgetown (8:0am);

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