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12-day Panama Canal Cruise from Miami

Panama Canal12-day Panama Canal cruise from Miami offers an unforgettable journey featuring vibrant cultures, stunning beaches, and exciting excursions. A 12-day cruise from Miami, Florida, is the perfect option to make a short getaway feel like a much longer period of repose, offering you the chance to unwind without the hassle. The beauty of a 12-day Eastern, Western, or Southern Caribbean cruise is that you only have to unpack once and settle into one room, yet still experience a rich variety of cultures, landscapes, and destinations. On a 12-day cruise, you'll see a wide variety of Western, Southern, or Eastern Caribbean ports and have ample time at sea to enjoy all of the incredible amenities and services on board, from world-class dining to luxurious staterooms and innovative lounges.

Panama Canal Ports of Call

Panama Canal cruise from Miami include stops in some of the most breathtaking beaches and crystal-clear waters in the world.

  • Panama: A Miami departure to Panama offers the unique experience of cruising through the iconic Panama Canal and exploring its surrounding tropical biodiversity.

Cruise lines departing from Miami

At PortMiami, cruisers are welcomed by the world's most renowned cruise lines, offering a variety of Panama Canal itineraries. Explore a 12-day cruise from Miami to multiple destinations.

  • Azamara Club Cruises: Embark on a luxurious journey in the Caribbean, where immersive experiences await you.
  • Norwegian Cruise Line: Cruise the Caribbean on your terms with diverse entertainment and freestyle cruising.
  • Oceania Cruises: Indulge in exquisite cuisine and refined exploration in the breathtaking Caribbean.
  • Regent Seven Seas Cruises: Discover the epitome of all-inclusive luxury at sea.
  • Royal Caribbean: Choose immersive cruising in the Caribbean, where innovative ships and unforgettable adventures await.

12-day Panama Canal Itineraries and Cruise Schedule from Miami

During your 12-day cruise through the Panama Canal, you will visit a wide variety of ports, and you will also have ample time at sea to take advantage of all of the incredible amenities and services that are offered on board, including world-class dining, luxurious staterooms, and cutting-edge lounges. Enjoy a Indulge in a 12-day trip from Miami to the islands of the Panama Canal, where you can relax in the warm water and soak up the sun.

Price from: $ 7,978
latest updates:

For the latest updates about this itinerary, check at Regent Seven Seas Cruises website
View Itinerary

12-day
Panama Canal
cruise from Miami
onboard Seven Seas Grandeur

Date: Saturday, January 3, 2026

Regent Seven Seas Cruises Panama Canal 12-day route to George Town, Ocho Rios, Bonaire, Curacao, Aruba, Cartagena, Puerto Limon, Panama Canal

Line Name: Regent Seven Seas Cruises

Ship Name: Seven Seas Grandeur

Duration: 12-day cruise

Cruise Type: One-way cruise


Ports of Call: Miami (5:00pm), George Town (9:00am-5:00pm), Ocho Rios (10:00am-6:00pm), Bonaire (10:00am-8:00pm), Curacao (7:00am-7:00pm), Aruba (7:00am-3:00pm), Cartagena (1:00pm-11:00pm), Puerto Limon (7:00am-4:00pm), Panama Canal (At Sea), Panama City (7:00am);