Miami Cruises MIAMI CRUISES

21-day Panama Canal Cruise from Miami

Panama Canal

Enjoy a once-in-a-lifetime experience aboard a 21-day Panama Canal cruise that departs from Miami. From Miami, Florida, cruises to the Panama Canal visit both Central American and Caribbean locations. Crossing the Panama Canal by ship is a once-in-a-lifetime experience. While going to or coming from the Panama Canal, one of the greatest man-made wonders in the world, go deep into the Panamanian rain forest, meet the locals, and learn how the locks work. During your 21-day cruise through the Panama Canal, you will visit a wide variety of ports, and you will also have ample time at sea to take advantage of all of the incredible amenities and services that are offered on board, including world-class dining, luxurious staterooms, and cutting-edge lounges. Enjoy a Indulge in a 21-day trip from Miami to the islands of the Panama Canal, where you can relax in the warm water and soak up the sun.


Find and plan your next 21-day Panama Canal cruise out of Miami

Norwegian Cruise Line Panama Canal 21-day route

21-day Panama Canal from Miami

Norwegian Encore, Norwegian Cruise Line

Date: April 7, 2024

Ports of Call: Miami, Cartagena, Panama Canal, Panama City, Puerto Quetzal, Acapulco, Puerto Vallarta, Cabo San Lucas, Los Angeles, San Francisco, San Francisco, Victoria, Seattle; View Itinerary

Oceania Cruises Panama Canal 21-day route

21-day Panama Canal from Miami

SIrena, Oceania Cruises

Date: February 8, 2025

Ports of Call: Miami, Cozumel, Costa Maya, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal, Panama City, Panama Canal, Cartagena, Santa Marta, Aruba, Curacao, Bonaire, Port Antonio, Nassau, Miami; View Itinerary